Samaneh Zolghadri Jahromi2; Majed Rezaeizadeh
Volume 6, Issue 3 , March 2018, , Pages 39-48
Abstract
The present study has investigated the effect of Iron nanoparticle on the ovary tissue lesion in the mice treated by isoniazid. In this study, 50 full-grown female rat divided randomly in five groups of eight rats. The control group received no treatment; the witness group received intraperitoneal (i.p.) ...
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The present study has investigated the effect of Iron nanoparticle on the ovary tissue lesion in the mice treated by isoniazid. In this study, 50 full-grown female rat divided randomly in five groups of eight rats. The control group received no treatment; the witness group received intraperitoneal (i.p.) isoniazid (50 mg/kg/bw , orally), group 2, group 3, and group 4 received 50 mg/kg isoniazid in combination with 150 and 250 mg/kg/bw respectively. Nanoparticles were intraperitoneally injected during 12 consequent days. After 24 hours, the nanoparticles in combination with isoniazid were injected again to the rats. On the 15th day, all groups were killed, dissected, and their ovaries removed for microscopic studies. After 15 days all rats were anatomized and their ovaries were taken out to be microscopically tested and put into ten percent formalin; the findings indicated the decrease of primary and secondary follicle (one and some layer), graph and yellow material in the group received isoniazid (P>0.05). The group received isoniazid and Nano ferrous oxide (150) show more significantly increase in primary and secondary follicles and graph and in the isoniazid and Nano ferrous oxide (250) primary, one layer, secondary and graph follicles show increase level compared to the isoniazid group (P>0.05). However, isoniazid had destroyed the ovary tissue in the groups who had received it and Nano ferrous oxide due to its antioxidant effects relatively decreased such effect.
